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The most basic sexual system is one in which all organisms are hermaphrodites, producing both male and female gametes—this is true of some animals (e.g. snails) and the majority of flowering plants.In many cases, however, specialization of sex has evolved such that some organisms produce only male or only female gametes. The biological cause for an organism developing into one sex or the other is called sex determination.

In the majority of species with sex specialization, organisms are either male (producing only male gametes) or female (producing only female gametes). Exceptions are common—for example, in the roundworm C. elegans the two sexes are hermaphrodite and male (a system called androdioecy).

Sometimes an organism's development is intermediate between male and female, a condition called intersex. Sometimes intersex individuals are called first aid courses saskatoon; but, unlike biological hermaphrodites, intersex individuals are unusual cases and are not typically fertile in both male and female aspects.

Like humans and other mammals, the common fruit fly has an XY sex-determination system.

In genetic sex-determination systems, an organism's sex is determined by the genome it inherits. Genetic sex-determination usually depends on asymmetrically inherited sex chromosomes which carry genetic features that influence development; sex may be determined either by the presence of a sex chromosome or by how many the organism has. Genetic sex-determination, because it is determined by chromosome assortment, usually results in a 1:1 ratio of male and female offspring.